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Mutational landscapes of brain metastases across various histological subtypes of lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2026

Nicoś Marcin, Stokowy Tomasz, Reszka Katarzyna, Kowalczyk Anna, Galant Natalia, Pęksa Rafał, Jarosz Bożena, Duchnowska Renata, Milanowski Janusz, Krawczyk Paweł, Jassem Jacek, Crosetto Nicola

Abstract excerpt

Knowledge of the genetic landscape of lung cancer brain metastases (BM) is limited due to the scarcity of intracranial samples. Here, we investigated the genetic features of 142 BM by next-generation sequencing in various lung cancer histological subtypes (19 small-cell lung cancer (SCLC), 123 non-small-cell lung cancer (NSCLC), including 79 lung adenocarcinomas (LUAD), 31 squamous carcinomas (LUSC), and 13...

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Identifiers

PMID: 41747607
DOI: 10.1016/j.lungcan.2026.109342

Genes

TP53
EGFR
NF1
PMS2
PTEN
RB1

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