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Clinicopathologic and Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases.

The oncologist - 1 Oct 2022

Huang Richard S P, Harries Lukas, Decker Brennan, Hiemenz Matthew C, Murugesan Karthikeyan, Creeden James, Tolba Khaled, Stabile Laura P, Ramkissoon Shakti H, Burns Timothy F, Ross Jeffrey S

Abstract excerpt

BACKGROUND: In patients with non-small cell lung cancer (NSCLC), 10%-40% will eventually develop brain metastases. We present the clinicopathologic, genomic, and biomarker landscape of a large cohort of NSCLC brain metastases (NSCLC-BM) samples. MATERIALS AND METHODS: We retrospectively analyzed 3035 NSCLC-BM tested with comprehensive genomic profiling (CGP) during routine clinical care. In addition, we compared...

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PMID: 35598205
DOI: 10.1093/oncolo/oyac094
PMCID: PMC9526503

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