Article
Trans-eQTLs of the CYP3A4 and CYP3A5 associated with tacrolimus trough blood concentration in Chinese renal transplant patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 2022
Lu Huijie, Jiang Haixia, Yang Siyao, Li Chengcheng, Li Chuanjiang, Shao Ruifan, Zhang Pai, Wang Daoyi, Liu Zhiwei, Qi Huana, Cai Yinuan, Xu Wenbin, Bao Xiaojie, Wang Hailan, Li Liang
Abstract excerpt
This study aimed to systematically investigate trans-eQTLs of CYP3A4 and CYP3A5 affecting tacrolimus trough blood concentrations in Chinese renal transplant patients. We used Plink v1.90 to perform data quality control and linear regression analysis on GTEx v8 data. SNPs with p-value < 0.05 were selected and the GTEx eQTL Calculator was used to further prioritize the eQTLs of CYP3A4 and CYP3A5 in the liver and...
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