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Article

Genomewide association study identifies a novel variant associated with tacrolimus trough concentration in Chinese renal transplant recipients.

Clinical and translational science - 1 Nov 2022

Yang Siyao, Jiang Haixia, Li Chengcheng, Lu Huijie, Li Chuanjiang, Ye Demei, Qi Huana, Xu Wenbin, Bao Xiaojie, Maseko Nicola, Zhang Siqi, Shao Ruifan, Li Liang

Abstract excerpt

Tacrolimus (TAC) is an immunosuppressant widely used in kidney transplantation. TAC displays considerable interindividual variability in pharmacokinetics (PKs). Genetic and clinical factors play important roles in TAC PKs. We enrolled a total of 251 Chinese renal transplant recipients and conducted a genomewide association study (GWAS), linkage disequilibrium (LD), and one-way analysis of variance (ANOVA) to find...

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Identifiers

PMID: 35977080
DOI: 10.1111/cts.13388
PMCID: PMC9652447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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