Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant.

doi:10.3390/genes15040497

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Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant.

Genes - 16 Apr 2024

Alatorre-Moreno Edith Viridiana, Saldaña-Cruz Ana Miriam, Pérez-Guerrero Edsaúl Emilio, Morán-Moguel María Cristina, Contreras-Haro Betsabé, López-de La Mora David Alejandro, Dávalos-Rodríguez Ingrid Patricia, Marín-Medina Alejandro, Rivera-Cameras Alicia, Balderas-Peña Luz-Ma Adriana, Gómez-Ramos José Juan, Cortés-Sanabria Laura, Salazar-Páramo Mario

Abstract excerpt

Tacrolimus (TAC) is an immunosuppressant drug that prevents organ rejection after transplantation. This drug is transported from cells via P-glycoprotein (ABCB1) and is a metabolic substrate for cytochrome P450 (CYP) 3A enzymes, particularly CYP3A4 and CYP3A5. Several single-nucleotide polymorphisms (SNPs) have been identified in the genes encoding CYP3A4, CYP3A5, and ABCB1, including CYP3A4-392A/G (rs2740574),...

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PMID: 38674430
DOI: 10.3390/genes15040497
PMCID: PMC11049954

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