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Article

Functional CYP3A variants affecting tacrolimus trough blood concentrations in Chinese renal transplant recipients.

The pharmacogenomics journal - 1 Jun 2021

Chen Dina, Lu Huijie, Sui Weiguo, Li Liqing, Xu Jian, Yang Tengfei, Yang Siyao, Zheng Ping, Chen Yan, Chen Jiejing, Xue Wen, Li Qingping, Zheng Que, Ye Demei, Sadee Wolfgang, Wang Danxin, Qian Wanying, Lai Liusheng, Li Chuanjiang, Li Liang

Abstract excerpt

The aim of this study was to identify novel genetic variants affecting tacrolimus trough blood concentrations. We analyzed the association between 58 single nucleotide polymorphisms (SNPs) across the CYP3A gene cluster and the log-transformed tacrolimus concentration/dose ratio (log (C0/D)) in 819 renal transplant recipients (Discovery cohort). Multivariate linear regression was used to test for associations...

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PMID: 33649515
DOI: 10.1038/s41397-021-00216-w

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