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Article

The genetic polymorphisms of POR28 and CYP3A53 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients.

International journal of clinical pharmacology and therapeutics - 1 Sept 2015

Zhang Jing-Jing, Liu Shuai-Bing, Xue Ling, Ding Xiao-Liang, Zhang Hua, Miao Li-Yan

Abstract excerpt

PURPOSES: The aims of this study were to assess the influence of the polymorphism of cytochrome P450 oxidoreductase (POR) as well as other relevant genes (CYP3A4, CYP3A5, ABCB1) on individual variability of tacrolimus pharmacokinetics and perform population pharmacokinetic analysis of tacrolimus in Chinese renal transplant recipients. METHODS: Tacrolimus trough whole blood concentrations and clinical details were...

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Share to Cytochrome P-450 CYP3A
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Source

Identifiers

PMID: 26227094
DOI: 10.5414/CP202152

Genes

POR
ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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