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Article

Effect of CYP3A5 Gene Polymorphisms on Tacrolimus Blood Concentrations and Adverse Events in Allogeneic Hematopoietic Stem Cell Transplant Patients.

Transplantation proceedings - 1 Sept 2024

Jiang Jia, Luan Jiajie

Abstract excerpt

BACKGROUND: Tacrolimus is the core basic immunosuppressant after transplantation. Cytochrome P450 3A5 (CYP3A5) is the main enzyme involved in tacrolimus metabolism, and rs776746A>G is the most frequently studied polymorphism in the CYP3A5 gene. The aim of this study was to investigate the effect of CYP3A5 gene polymorphisms on tacrolimus blood concentrations and acute graft versus host disease (GVHD) in patients...

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Identifiers

PMID: 39147616
DOI: 10.1016/j.transproceed.2024.08.012

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