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Mechanisms of muscle growth and atrophy in mammals and Drosophila

29 Aug 2013

Abstract excerpt

BACKGROUND: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. RESULTS: In this review, we highlight the outstanding unsolved questions that may...

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PMID: 24038488
DOI: 10.1002/dvdy.24036

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