Article

Matrisome gene expression is altered during non-allometric heart growth in genetically enlarged <i>Drosophila</i>

2024-03-27

Abstract excerpt

The cardiac extracellular matrix (ECM) is critical to defining the biophysical properties of the heart that adapt to changing stresses with growth or disease. The ECM is commonly dysregulated in chronic disease such as hypertension, diabetes, and cardiomyopathies, often leading to the development of fibrosis. There are no treatment options to address most ECM cardiomyopathies, but developing therapeutic targets ne...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e020a08c-93d3-5fac-9a3e-d4b3bbad1849
DOI: 10.1101/2024.03.25.586620

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Matrisome gene expression is altered during non-allometric heart growth in genetically enlarged <i>Drosophila</i>DOI 10.1101/2024.03.25.586620Read

Cardiac function and ECM morphology are altered with high fat diets in <i>Drosophila</i>Semantic proximity Read

A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in DrosophilaSemantic proximity Read

Mechanotransduction coordinates extracellular matrix protein homeostasis promoting longevity in <i>C. elegans</i>Semantic proximity Read

Measuring passive myocardial stiffness in <i><scp>D</scp>rosophila melanogaster</i> to investigate diastolic dysfunctionSemantic proximity Read

Modeling exercise using optogenetically contractible <i>Drosophila</i> larvaeSemantic proximity Read

Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in DrosophilaSemantic proximity Read

Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagenSemantic proximity Read

<i>In-silico</i> definition of the <i>Drosophila melanogaster</i> matrisomeSemantic proximity Read

The impact of SPARC on age-related cardiac dysfunction and fibrosis in DrosophilaSemantic proximity Read

Rewiring Fibroblast–Muscle Axis Drives Progressive Pathology in Bethlem MyopathySemantic proximity Read

Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.Semantic proximity Read

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expressionSemantic proximity Read