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Article

JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition.

The Journal of allergy and clinical immunology - 1 Oct 2021

Luo Yiming, Alexander Madison, Gadina Massimo, O'Shea John J, Meylan Francoise, Schwartz Daniella M

Abstract excerpt

Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-STAT) pathway has become recognized as a central mediator of widespread and varied human physiological processes. The field of JAK-STAT biology, particularly its clinical relevance, continues to be shaped by 2 important advances. First, the increased use of genomic sequencing has led to the discovery of novel clinical...

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Identifiers

PMID: 34625141
DOI: 10.1016/j.jaci.2021.08.004
PMCID: PMC8514054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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