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Article

JAK‐STAT core cancer pathway: An integrative cancer interactome analysis

1 Mar 2022

Abstract excerpt

Through a comprehensive review and in silico analysis of reported data on STAT-linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for therapeutic intervention to disrupt critical pathways and addictions to hyperactive JAK/STAT in neoplastic states. Although all STATs follow a similar molecular activation...

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PMID: 35229974
DOI: 10.1111/jcmm.17228

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