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Article

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.

Human molecular genetics - 15 Mar 2016

Vázquez-Manrique Rafael P, Farina Francesca, Cambon Karine, Dolores Sequedo María, Parker Alex J, Millán José María, Weiss Andreas, Déglon Nicole, Neri Christian

Abstract excerpt

The adenosine monophosphate activated kinase protein (AMPK) is an evolutionary-conserved protein important for cell survival and organismal longevity through the modulation of energy homeostasis. Several studies suggested that AMPK activation may improve energy metabolism and protein clearance in the brains of patients with vascular injury or neurodegenerative disease. However, in Huntington's disease (HD), AMPK...

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Identifiers

PMID: 26681807
DOI: 10.1093/hmg/ddv513
PMCID: PMC4764188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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