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Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases

28 Jul 2021

Abstract excerpt

Impaired energy homeostasis and aberrant translational control have independently been implicated in the pathogenesis of neurodegenerative diseases. AMP kinase (AMPK), regulated by the ratio of cellular AMP and ATP, is a major gatekeeper for cellular energy homeostasis. Abnormal regulation of AMPK has been reported in several neurodegenerative diseases, including Alzheimer's disease (AD) and amyotrophic lateral...

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PMID: 34393724
DOI: 10.3389/fncel.2021.668500

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