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AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in<i>Drosophila</i>Models of Parkinson's Disease

10 Oct 2012

Abstract excerpt

Mutations in parkin and LRRK2 together account for the majority of familial Parkinson's disease (PD) cases. Interestingly, recent evidence implicates the involvement of parkin and LRRK2 in mitochondrial homeostasis. Supporting this, we show here by means of the Drosophila model system that, like parkin, LRRK2 mutations induce mitochondrial pathology in flies when expressed in their flight muscles, the toxic...

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PMID: 23055502
DOI: 10.1523/jneurosci.0499-12.2012

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