Article
Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease.
Neurobiology of aging - 1 Jul 2017
Ng Chee-Hoe, Basil Adeline H, Hang Liting, Tan Royston, Goh Kian-Leong, O'Neill Sharon, Zhang Xiaodong, Yu Fengwei, Lim Kah-Leong
Abstract excerpt
Despite intensive research, the etiology of Parkinson's disease (PD) remains poorly understood and the disease remains incurable. However, compelling evidence gathered over decades of research strongly support a role for mitochondrial dysfunction in PD pathogenesis. Related to this, PGC-1α, a key regulator of mitochondrial biogenesis, has recently been proposed to be an attractive target for intervention in PD....
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