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Article

Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Jan 2012

Lim M A, Selak M A, Xiang Z, Krainc D, Neve R L, Kraemer B C, Watts J L, Kalb R G

Abstract excerpt

A growing body of research indicates that amyotrophic lateral sclerosis (ALS) patients and mouse models of ALS exhibit metabolic dysfunction. A subpopulation of ALS patients possesses higher levels of resting energy expenditure and lower fat-free mass compared to healthy controls. Similarly, two mutant copper zinc superoxide dismutase 1 (mSOD1) mouse models of familial ALS possess a hypermetabolic phenotype. The...

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Identifiers

PMID: 22262909
DOI: 10.1523/JNEUROSCI.6554-10.2012
PMCID: PMC3742882

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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