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Article

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

Molecular neurodegeneration - 3 Nov 2017

Bobela Wojciech, Nazeeruddin Sameer, Knott Graham, Aebischer Patrick, Schneider Bernard L

Abstract excerpt

BACKGROUND: Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson's disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to neurodegeneration. METHODS: Here, we overexpress various genetic variants of the catalytic AMPKα subunit to determine how AMPK activity affects the survival and function of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29100525
DOI: 10.1186/s13024-017-0220-x
PMCID: PMC5670705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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