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Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy

11 Nov 2021

Abstract excerpt

Acute myeloid leukemia (AML) is a malignancy of immature progenitor cells. AML differentiation therapies trigger leukemia maturation and can induce remission, but relapse is prevalent and its cellular origin is unclear. Here we describe high resolution analysis of differentiation therapy response and relapse in a mouse AML model. Triggering leukemia differentiation in this model invariably produces two...

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PMID: 34764270
DOI: 10.1038/s41467-021-26849-w

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