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Article

Long-term observation reveals high-frequency engraftment of human acute myeloid leukemia in immunodeficient mice

9 Feb 2017

Abstract excerpt

Repopulation of immunodeficient mice remains the primary method for functional assessment of human acute myeloid leukemia. Published data report engraftment in ~40–66% of cases, mostly of intermediate- or poor-risk subtypes. Here we report that extending follow-up beyond the standard analysis endpoints of 10 to 16 weeks after transplantation permitted leukemic engraftment from nearly every case of...

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PMID: 28183848
DOI: 10.3324/haematol.2016.153528

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