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The journey of neutropoiesis: how complex landscapes in bone marrow guide continuous neutrophil lineage determination

5 Jan 2022

Abstract excerpt

Neutrophils are the most abundant white blood cell, and they differentiate in homeostasis in the bone marrow from hematopoietic stem cells (HSCs) via multiple intermediate progenitor cells into mature cells that enter the circulation. Recent findings support a continuous model of differentiation in the bone marrow of heterogeneous HSCs and progenitor populations. Cell fate decisions at the levels of proliferation...

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Share to Hematological disorders and diagnostics
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PMID: 34986245
DOI: 10.1182/blood.2021012835

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