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Article

Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation.

Cancer letters - 28 Jun 2007

Elagib Kamaleldin E, Goldfarb Adam N

Abstract excerpt

The leukemic fusion protein AML1-ETO occurs frequently in human acute myeloid leukemia (AML) and has received much attention over the past decade. An initial model for its pathogenetic effects emphasized the conversion of a hematopoietic transcriptional activator, RUNX1 (or AML1), into a leukemogenic repressor which blocked myeloid differentiation at the level of target gene regulation. This view has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

Source

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Identifiers

PMID: 17125917
DOI: 10.1016/j.canlet.2006.10.010
PMCID: PMC1931834

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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