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Transplantation in neonate mouse recipients enhances umbilical cord blood CD34 <sup>+</sup> cells permissiveness to ETO2::GLIS2-driven transformation

2026-01-13

Abstract excerpt

Acute megakaryoblastic leukemia (AMKL) is a rare and aggressive pediatric acute myeloid leukemia subtype, frequently driven by the ETO2::GLIS2 (EG) gene fusion in de novo AMKL patients. The EG fusion confers poor prognosis and high relapse risk. In a previous study, we demonstrated that human fetal hematopoietic cells are intrinsically permissive to EG-driven transformation and that microenvironmental cues critica...

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Literature Corpus work
5dc663f3-09e3-5b8a-978a-d46c528c493d
DOI
10.64898/2026.01.12.698953
Open publication

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Transplantation in neonate mouse recipients enhances umbilical cord blood CD34 <sup>+</sup> cells permissiveness to ETO2::GLIS2-driven transformationDOI 10.64898/2026.01.12.698953
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