Article
Tracing the origins of relapse in acute myeloid leukaemia to stem cells.
Nature - 6 Jul 2017
Shlush Liran I, Mitchell Amanda, Heisler Lawrence, Abelson Sagi, Ng Stanley W K, Trotman-Grant Aaron, Medeiros Jessie J F, Rao-Bhatia Abilasha, Jaciw-Zurakowsky Ivana, Marke Rene, McLeod Jessica L, Doedens Monica, Bader Gary, Voisin Veronique, Xu ChangJiang, McPherson John D, Hudson Thomas J, Wang Jean C Y, Minden Mark D, Dick John E
Abstract excerpt
In acute myeloid leukaemia, long-term survival is poor as most patients relapse despite achieving remission. Historically, the failure of therapy has been thought to be due to mutations that produce drug resistance, possibly arising as a consequence of the mutagenic properties of chemotherapy drugs. However, other lines of evidence have pointed to the pre-existence of drug-resistant cells. For example, deep...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.