In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.

doi:10.1016/j.ccr.2008.05.015

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Article

In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.

Cancer cell - 8 Jul 2008

le Viseur Christoph, Hotfilder Marc, Bomken Simon, Wilson Kerrie, Röttgers Silja, Schrauder André, Rosemann Annegret, Irving Julie, Stam Ronald W, Shultz Leonard D, Harbott Jochen, Jürgens Heribert, Schrappe Martin, Pieters Rob, Vormoor Josef

Abstract excerpt

We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia (ALL). Human leukemic bone marrow was transplanted intrafemorally into NOD/scid mice. Cells sorted using the B precursor differentiation markers CD19, CD20, and CD34 were isolated from patient samples and engrafted mice before serial transplantation into primary or subsequent (up to...

Topics

Adolescent
Animals
Antigens, CD19
Antigens, CD20
Antigens, CD34
B-Lymphocytes
Bone Marrow Transplantation
Cell Differentiation
Cell Line, Tumor
Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cell Proliferation

Cell Separation

Child, Preschool

Flow Cytometry

Gene Expression Regulation, Leukemic

Humans

Immunoglobulins

Immunophenotyping

Source

Open in PubMed Open full text

Identifiers

PMID: 18598943
DOI: 10.1016/j.ccr.2008.05.015
PMCID: PMC2572185

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