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Article

Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans.

Genetics - 1 Apr 2007

Tarailo Maja, Kitagawa Risa, Rose Ann M

Abstract excerpt

The spindle assembly checkpoint (SAC) governs the timing of metaphase-to-anaphase transition and is essential for genome stability. The Caenorhabditis elegans mutant strain gk2 carries a deletion within the mdf-1/MAD1 gene that results in death of the homozygous strain after two or three generations. Here we describe 11 suppressors of the mdf-1(gk2) lethality, 10 identified in an ethyl methanesulfonate (EMS)...

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Identifiers

PMID: 17237515
DOI: 10.1534/genetics.106.067918
PMCID: PMC1855113

Genes

APC
CDC20

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans.PMID 17237515Read ↗

Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans.Semantic proximity Read ↗

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.Semantic proximity Read ↗

Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components.Semantic proximity Read ↗

Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.Semantic proximity Read ↗

Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans.Semantic proximity Read ↗

Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.Semantic proximity Read ↗

A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans.Semantic proximity Read ↗

Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.Semantic proximity Read ↗

emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.Semantic proximity Read ↗

The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.Semantic proximity Read ↗

EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.Semantic proximity Read ↗

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