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Meiotic spindle assembly checkpoint and aneuploidy in males versus females

18 Dec 2018

Abstract excerpt

The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including...

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PMID: 30564841
DOI: 10.1007/s00018-018-2986-6

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