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Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway.

Stem cells (Dayton, Ohio) - 1 Mar 2015

Gargini Ricardo, Cerliani Juan P, Escoll Maribel, Antón Inés M, Wandosell Francisco

Abstract excerpt

Many solid tumors contain a subpopulation of cells with stem characteristics and these are known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). These cells drive tumor growth and appear to be regulated by molecular pathway different from other cells in the tumor bulk. Here, we set out to determine whether elements of the PI3K-AKT pathway are necessary to maintain the CSC-like phenotype in breast...

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PMID: 25407338
DOI: 10.1002/stem.1904

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AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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