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Article

Correlation of breast cancer axillary lymph node metastases with stem cell mutations.

JAMA surgery - 1 Sept 2013

Donovan Cory A, Pommier Rodney F, Schillace Robynn, O'Neill Steven, Muller Patrick, Alabran Jennifer L, Hansen Juliana E, Murphy Jennifer A, Naik Arpana M, Vetto John T, Pommier Suellen J

Abstract excerpt

IMPORTANCE: Mutations in oncogenes AKT1, HRAS, and PIK3CA in breast cancers result in abnormal PI3K/Akt signaling and tumor proliferation. They occur in ductal carcinoma in situ, in breast cancers, and in breast cancer stem and progenitor cells (BCSCs). OBJECTIVES: To determine if variability in clinical presentation at diagnosis correlates with PI3K/Akt mutations in BCSCs and provides an early prognostic...

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Share to Carcinoma, Ductal, Breast
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23884447
DOI: 10.1001/jamasurg.2013.3028

Genes

AKT1
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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