Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

2 Oct 2007

Abstract excerpt

Side-population (SP) cells within cancers and cell lines are rare cell populations known to enrich cancer stem-like cells. In this study, we characterized SP cells from the human breast cancer cell line MCF7 as a model for cancer stem-like cells. Compared with non-SP cells, MCF7 SP cells had higher colony-formation ability in vitro and greater tumorigenicity in vivo, suggesting that MCF7 SP cells enrich cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17911267
DOI: 10.1073/pnas.0702596104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenancePMID 17911267Read ↗

Pathways of Proliferation and Antiapoptosis Driven in Breast Cancer Stem Cells by Stem Cell Protein Piwil2Semantic proximity Read ↗

PI3K/Akt/mTOR signaling pathway in cancer stem cellsSemantic proximity Read ↗

Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway.Semantic proximity Read ↗

Targeted therapy of cancer stem cells: inhibition of mTOR in pre-clinical and clinical researchSemantic proximity Read ↗

Cancer Stem Cell Transcriptome Landscape Reveals Biomarkers Driving Breast Cancer HeterogeneitySemantic proximity Read ↗

PTEN Tumor-Suppressor: The Dam of Stemness in CancerSemantic proximity Read ↗

Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.Semantic proximity Read ↗

Targeting breast cancer stem cellsSemantic proximity Read ↗

Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad SignalingSemantic proximity Read ↗

Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expressionSemantic proximity Read ↗

miR‐99a directly targets the <scp>mTOR</scp> signalling pathway in breast cancer side population cellsSemantic proximity Read ↗

Identification of Breast Cancer Stem Cell Related Genes Using Functional Cellular Assays Combined With Single-Cell RNA Sequencing in MDA-MB-231 CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.