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Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

18 Oct 2021

Abstract excerpt

Abstract In contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T cell activity, only modest responses are achieved with checkpoint-blockade therapy, which might be explained by T cell phenotypes and T cell receptor (TCR) repertoires. Here, we show by paired single-cell RNA analysis and TCR repertoire profiling of bone marrow cells in relapsed/refractory acute...

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PMID: 34663807
DOI: 10.1038/s41467-021-26282-z

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