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Article

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.

Nature communications - 8 Nov 2021

Matsuda Shinya, Schaefer Jonas V, Mii Yusuke, Hori Yutaro, Bieli Dimitri, Taira Masanori, Plückthun Andreas, Affolter Markus

Abstract excerpt

How morphogen gradients control patterning and growth in developing tissues remains largely unknown due to lack of tools manipulating morphogen gradients. Here, we generate two membrane-tethered protein binders that manipulate different aspects of Decapentaplegic (Dpp), a morphogen required for overall patterning and growth of the Drosophila wing. One is "HA trap" based on a single-chain variable fragment (scFv)...

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Source

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Identifiers

PMID: 34750371
DOI: 10.1038/s41467-021-26726-6
PMCID: PMC8576045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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