Article
The range of spalt-activating Dpp signalling is reduced in endocytosis-defective Drosophila wing discs.
Mechanisms of development - 1 Sept 1999
González-Gaitán M, Jäckle H
Abstract excerpt
Pattern formation along the anterior-posterior (A/P) axis of the developing Drosophila wing depends on Decapentaplegic (Dpp), a member of the conserved transforming growth factor beta (TGFbeta) family of secreted proteins. Dpp is expressed in a stripe along the A/P compartment boundary of the wing imaginal disc and forms a long-range concentration gradient with morphogen-like properties which generates distinct...
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