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Article

Formation of the long range Dpp morphogen gradient.

PLoS biology - 1 Jul 2011

Schwank Gerald, Dalessi Sascha, Yang Schu-Fee, Yagi Ryohei, de Lachapelle Aitana Morton, Affolter Markus, Bergmann Sven, Basler Konrad

Abstract excerpt

The TGF-β homolog Decapentaplegic (Dpp) acts as a secreted morphogen in the Drosophila wing disc, and spreads through the target tissue in order to form a long range concentration gradient. Despite extensive studies, the mechanism by which the Dpp gradient is formed remains controversial. Two opposing mechanisms have been proposed: receptor-mediated transcytosis (RMT) and restricted extracellular diffusion (RED)....

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Identifiers

PMID: 21814489
DOI: 10.1371/journal.pbio.1001111
PMCID: PMC3144185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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