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Article

Dopamine D2 receptor regulates cortical synaptic pruning in rodents.

Nature communications - 8 Nov 2021

Zhang Ya-Qiang, Lin Wei-Peng, Huang Li-Ping, Zhao Bing, Zhang Cheng-Cheng, Yin Dong-Min

Abstract excerpt

Synaptic pruning during adolescence is important for appropriate neurodevelopment and synaptic plasticity. Aberrant synaptic pruning may underlie a variety of brain disorders such as schizophrenia, autism and anxiety. Dopamine D2 receptor (Drd2) is associated with several neuropsychiatric diseases and is the target of some antipsychotic drugs. Here we generate self-reporting Drd2 heterozygous (SR-Drd2+/-) rats to...

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Identifiers

PMID: 34750364
DOI: 10.1038/s41467-021-26769-9
PMCID: PMC8576001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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