Article

Dopamine D2 receptors in mossy cells reduce excitatory transmission and are essential for hippocampal function

2023-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Hilar mossy cells (MCs) are principal excitatory neurons of the dentate gyrus (DG) that play critical roles in hippocampal function and have been implicated in brain disorders such as anxiety and epilepsy. However, the mechanisms by which MCs contribute to DG function and disease are poorly understood. Expression from the dopamine D2 receptor (D2R) gene ( Drd2 ) promoter is a defining feature o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30a4588b-38fb-58a9-9b42-dcf4b0f2acd9
DOI: 10.1101/2023.05.05.539468

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dopamine D2 receptors in mossy cells reduce excitatory transmission and are essential for hippocampal functionDOI 10.1101/2023.05.05.539468Read

The correct temporal connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signalingSemantic proximity Read

Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.Semantic proximity Read

GluD1 Modulates GluN2B-containing NMDAR Function and Plasticity at Subicular SynapsesSemantic proximity Read

Dopamine D2 receptor regulates cortical synaptic pruning in rodents.Semantic proximity Read

( <i>R,S</i> )-ketamine’s rapid-acting antidepressant effects are modulated by NR2B-containing NMDA receptors on adult-born hippocampal neuronsSemantic proximity Read

Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice.Semantic proximity Read

Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy.Semantic proximity Read

Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice.Semantic proximity Read

Hypothalamic-pituitary-adrenal axis dysfunction worsens epilepsy outcomes and increases SUDEP riskSemantic proximity Read

Physiological and morphological characterization of dentate granule cells in the p35 knock-out mouse hippocampus: evidence for an epileptic circuit.Semantic proximity Read

Deletion of dopamine D2 receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes.Semantic proximity Read

Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.Semantic proximity Read