Article
Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
The Journal of clinical investigation - 1 Dec 2017
Li Yan, Yin Anqi, Sun Xin, Zhang Ming, Zhang Jianfang, Wang Ping, Xie Rougang, Li Wen, Fan Ze, Zhu Yuanyuan, Wang Han, Dong Hailong, Wu Shengxi, Xiong Lize
Abstract excerpt
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent psychiatric disorder in children. Although an imbalance of excitatory and inhibitory inputs has been proposed as contributing to this disorder, the mechanisms underlying this highly heterogeneous disease remain largely unknown. Here, we show that N-myc downstream-regulated gene 2 (NDRG2) deficiency is involved in the development of ADHD in both mice...
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