Article
Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis.
Science (New York, N.Y.) - 5 Nov 2021
Avagyan S, Henninger J E, Mannherz W P, Mistry M, Yoon J, Yang S, Weber M C, Moore J L, Zon L I
Abstract excerpt
Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique that combines mosaic mutagenesis with color labeling of HSPCs to study how acquired mutations affect clonal fitness in a native environment. Mutations in clonal hematopoiesis–associated genes such as asxl1 promoted clonal dominance....
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