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Article

Discovering early molecular determinants of leukemogenesis.

The Journal of clinical investigation - 1 Mar 2008

Bagby Grover C

Abstract excerpt

Truncating mutations of the G-CSF receptor are found during disease course in nearly half of all patients with severe congenital neutropenia. In this issue of the JCI, Liu et al. demonstrate that these mutations confer a competitive clonal advantage upon HSCs in mice and that the advantage is conditional because it is observed only in the presence of the ligand G-CSF (see the related article beginning on page...

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Source

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Identifiers

PMID: 18292805
DOI: 10.1172/JCI35109
PMCID: PMC2248429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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