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Article

Aging in the bone marrow: when hematopoiesis gets clonal.

Current opinion in hematology - 1 Jul 2026

Bowdish Dawn M E, Quin Candice

Abstract excerpt

PURPOSE OF REVIEW: It has been known that the cytokine TNF (tumor necrosis factor alpha) influences hematopoiesis for decades. We now know that increases in TNF in the aging microenvironment favor the persistence and expansion of myeloid progenitors, especially those that contain mutations associated with clonal hematopoiesis of indeterminate potential (CHIP). Herein, we will examine both seminal and recent...

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Identifiers

PMID: 42089539
DOI: 10.1097/MOH.0000000000000928

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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