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Article

Truncated CSF3 receptors induce pro-inflammatory responses in severe congenital neutropenia.

British journal of haematology - 1 Jan 2023

Olofsen Patricia A, Bosch Dennis A, de Looper Hans W J, van Strien Paulina M H, Hoogenboezem Remco M, Roovers Onno, van der Velden Vincent H J, Bindels Eric M J, De Pater Emma M, Touw Ivo P

Abstract excerpt

Severe congenital neutropenia (SCN) patients are prone to develop myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). Leukaemic progression of SCN is associated with the early acquisition of CSF3R mutations in haematopoietic progenitor cells (HPCs), which truncate the colony-stimulating factor 3 receptor (CSF3R). These mutant clones may arise years before MDS/AML becomes overt. Introduction and...

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Identifiers

PMID: 36168923
DOI: 10.1111/bjh.18477
PMCID: PMC10087386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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