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Article

Chronic interleukin-1 exposure triggers selection for Cebpa -knockout multipotent hematopoietic progenitors

25 Mar 2021

Abstract excerpt

The early events that drive myeloid oncogenesis are not well understood. Most studies focus on the cell-intrinsic genetic changes and how they impact cell fate decisions. We consider how chronic exposure to the proinflammatory cytokine, interleukin-1β (IL-1β), impacts Cebpa-knockout hematopoietic stem and progenitor cells (HSPCs) in competitive settings. Surprisingly, we found that Cebpa loss did not confer a...

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PMID: 33914855
DOI: 10.1084/jem.20200560

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