Article

Dominant Malignant Clones Leverage Lineage Restricted Epigenomic Programs to Drive Ependymoma Development

2024-08-15

Abstract excerpt

<h4>ABSTRACT</h4> ZFTA-RELA is the most recurrent genetic alteration seen in pediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumors in mice. Despite ZFTA-RELA’s potent oncogenic potential, ZFTA-RELA gene fusions are observed exclusively in childhood EPN, with tumors located distinctly in the supratentorial region of the central nervous system (CNS). We hypothesized that specific chromatin...

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Literature Corpus work: efd2feb3-c3d8-5bd8-a30c-6247ec339ae0
DOI: 10.1101/2024.08.12.607603

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