Article
SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice.
Cell reports - 2 Nov 2021
Yang Kan, Shi Yuhan, Du Xiujuan, Wang Jincheng, Zhang Yuefang, Shan Shifang, Yuan Yiting, Wang Ruoqing, Zhou Chenhuan, Liu Yuting, Cai Zilin, Wang Yanzhi, Fan Liu, Xu Huatai, Yu Juehua, Cheng Jinke, Li Fei, Qiu Zilong
Abstract excerpt
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, causing defects of social interaction and repetitive behaviors. Here, we identify a de novo heterozygous gene-truncating mutation of the Sentrin-specific peptidase1 (SENP1) gene in people with ASD without neurodevelopmental delay. We find that Senp1+/- mice exhibit core autistic-like symptoms such as social deficits and repetitive...
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