SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice

Abstract excerpt

Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, in which core symptoms are defects of social interaction and evidently repetitive behaviors. Although around 50-70 % of ASD patients have comorbidity of intellectual disabilities (ID) or developmental delay (DD), there are some ASD patients who exhibit only core symptoms but without ID/DD, raising the question whether there are genet...

Topics

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• Excitatory Postsynaptic Potentials
• Fragile X Mental Retardation Protein
• Grooming
• Gyrus Cinguli
• Haploinsufficiency
• Locomotion
• Maze Learning
• Sumoylation

Identifiers and source

Literature Corpus work

2deebff7-e0b1-571c-a248-95b321294344

DOI

10.1101/2021.01.24.427868