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DLC3/Cv-c function in testis development in humans and Drosophila: implication for variants of sex development

2022-08-01

Abstract excerpt

Identifying genes affecting gonad development is essential to understand the mechanisms causing Variants/Differences in Sex Development. Recently, a DLC3 mutation was associated with male gonadal dysgenesis in 46,XY DSD patients. We show that Cv-c, the Drosophila ortholog of DLC3, is also required to maintain testis integrity during fly development. We found that Cv-c and human DLC3 can perform the same function...

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Literature Corpus work
3409f18b-1a3a-5d82-b1d8-1a7ffc0302ae
DOI
10.1101/2022.07.28.501838
Open publication

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