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Article

Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.

PLoS biology - 1 Nov 2021

Chauve Laetitia, Hodge Francesca, Murdoch Sharlene, Masoudzadeh Fatemeh, Mann Harry-Jack, Lopez-Clavijo Andrea F, Okkenhaug Hanneke, West Greg, Sousa Bebiana C, Segonds-Pichon Anne, Li Cheryl, Wingett Steven W, Kienberger Hermine, Kleigrewe Karin, de Bono Mario, Wakelam Michael J O, Casanueva Olivia

Abstract excerpt

To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal heat shock factor 1 (HSF-1), the conserved master regulator of the heat shock response (HSR), causes extensive fat remodeling in peripheral tissues. These changes include a...

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PMID: 34723964
DOI: 10.1371/journal.pbio.3001431
PMCID: PMC8585009

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