Article

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin

2023-07-25

Abstract excerpt

Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here we show that early-life thermal stress strongly up-regulates tsp-1 , a gene encoding the conserved transmembrane tetraspanin in C. elegans . TSP-1 forms prominent multimers and stable web- like structures critical for membrane barr...

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Literature Corpus work: 2727b677-6e90-5ce6-aa64-fb9d1d304ed8
DOI: 10.1101/2023.07.25.550452

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