Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2.

doi:10.1534/genetics.118.301272

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Article

Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2.

Genetics - 1 Sept 2018

Bodhicharla Rakesh, Devkota Ranjan, Ruiz Mario, Pilon Marc

Abstract excerpt

Maintenance of membrane properties is an essential aspect of cellular homeostasis of which the regulatory mechanisms remain mostly uncharacterized. In Caenorhabditis elegans, the PAQR-2 and IGLR-2 proteins act together as a plasma membrane sensor that responds to decreased fluidity by promoting fatty acid desaturation, hence restoring membrane fluidity. Here, we used mosaic analysis for paqr-2 and iglr-2, and...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Membrane
Fatty Acids
HEK293 Cells
Homeostasis
Humans
Membrane Fluidity
Membrane Proteins
Mutation
Phenotype
RNA, Small Interfering
Receptors, Adiponectin
Stearoyl-CoA Desaturase

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Identifiers

PMID: 29997234
DOI: 10.1534/genetics.118.301272
PMCID: PMC6116961

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