Article

Transcriptional landscape of a hypoxia response identifies cell-specific pathways for adaptation

2024-07-04

Abstract excerpt

How the HIF-1 (Hypoxia-Inducible) transcription factor drives and coordinates distinct responses to low oxygen across diverse cell types is poorly understood. We present a multi-tissue single-cell gene-expression atlas of the hypoxia response of the nematode Caenorhabditis elegans . This atlas highlights how cell-type-specific HIF-1 responses overlap and diverge among and within neuronal, intestinal, and muscle t...

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Literature Corpus work: 5e4212ee-7108-5d3e-92fb-959f0112c93c
DOI: 10.1101/2024.07.02.601765

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